Principal Investigator. Associate Professor University of Texas Medical Branch, Department of Neuroscience, Cell Biology and Anatomy.
Dr. Eliseo Eugenin received his doctorates in Physiological Sciences in 2001 from Pontificia Universidad Católica de Chile. In 2000, while he was doing his Ph.D. he received the DAAD fellowship from Germany to perform studied in Bonn University. During his Ph.D. thesis, he discovers that pannexin-1 and connexin hemichannels are open in response to several pathogenic conditions, including HIV, ALS and brain cancer. In 2012 when he was working as an assistant professor at the Pathology Department in Albert Einstein College of Medicine, Dr. Eugenin was awarded a grant from the Nation Institute of Health (NIH) to study the role of connexin-43 containing channels in astrocytes in the pathogenesis of CNS HIV disease. Later he starts a successful career as associated professor in the Public Health Research Institute (PHRI) in University of Rutgers Medical School, resulted in numerous high impact publications, patents and pharmaceutical collaboration; with the purpose of translating his research into therapies.
During the last 15 years, Dr. Eugenin has been working in Immunology and Neuroscience with a unique training and expertise in channel biology. His recent work focuses on proving how these channels are essential for ATP release into the extracellular space, enabling activation of inflammation, HIV entry, transmigration, and CNS damage. His research is an integral part of the public health research, participating in NIH study sections related with NeuroAIDS and HIV reservoirs. Currently, Dr. Eugenin is a faculty member of the University of Texas Medical Branch (UTMB). His laboratory main focuses of research are:
- The role of connexin and pannexin containing channels, gap junctions, and hemichannels, in the pathogenesis of NeuroHIV.
- The role of pannexin-1 hemichannels, purinergic receptors, and ATP in the HIV life cycle.
- Examine the role of tunneling nanotubes (TNT) in HIV spread and infection between immune cells and the role of TNT in glioblastoma development and spread of resistance.
- Biomarkers of CNS disease: Focus on TNT and nucleotide.